Knowledge: Soursop Leaf (Annona Muricata)

Soursop Leaf (Annona Muricata)

Soursop Leaf (Annona muricata)

The popular fruit tree of Annona muricata (Annonaceae) commonly known as graviola or soursop is commercially cultured in Central and South America and tropical countries. The edible fruit of this small tropical tree is extensively used to produce candy, juice, smoothies, ice-cream and other sweet treats. In addition, this plant is also important due to its various applications in folk medicine. All parts of this plant, including the bark, fruit-seeds, leaves and root are used in natural medicines in the tropics. Traditionally, the leaves are used for cystitis, diabetes, headaches, hypertension, insomnia, liver problems and against skin diseases. Many people also use the soursop leaves to make tea.

Pure Soursop Leaf Annona muricata Extract must have Acetogenins!

Without Acetogenins, its not Soursop Leaf Annona muricata! 0.01-0.02% Acetogenins (Bioactive Phytochemicals)

No harm/chemicals/preservative, just harmony, manufactured naturally

  • Vegan
  • Non-GMO
  • No Fillers
  • No Flavors
  • No Additives
  • No Preservatives
  • No Artificial Colors
  • Soy and Gluten Free
  • Lab Tested for Authentic & Active Compound
  • Origin from Malaysia Farm
BIONUTRICIA Annona muricata Soursop Leaf Extract BRAND X
Certification Registered with the Ministry of Health, Halal Tested Not registered & certified
Raw Ingredients Annona muricata Soursop Leaf Extract from Malaysia Very little / no raw ingredients; Use non-Soursop Leaf materials
Process Extracted through R.O. water & Ultra-sonic; Full bio-active ingredients Grinded plant powder; Extracted through ethanol process
Active Compound Tested with high amount of Acetogenins Not Tested
Formulation Only Soursop Leaf – which is proven safe and effective Combination of other ingredients (effectiveness & safety is not proven); Added with prohibited drugs
Label Transparent, standardized Annona muricata Soursop Leaf Extract 0.01-0.02% Acetogenins Misleading claim (quantity), incorrect amount of Soursop Leaf extract, mostly filler ingredients

HALAL Certificate & High Standard Product Quality Control


Blood Sugar Control

In vivo study on effect of soursop leaf extract on blood sugar
Subject Male rats (n=50)
Duration of the study 58 days
Dosage 50, 100, 150mg/kg
  1. Negative control (Hyperglycemia)
  2. Positive control (Non hyperglycemia)
  3. Treatment (50mg/kg)
  4. Treatment (100mg/kg)
  5. Treatment (150mg/kg)
Parameters analysed Fasting blood glucose level & pancreatic beta cell number
Soursop leaf extract can be used to treat diabetic individuals by lowering blood sugar and increasing beta cell number.
Visible benefits
The soursop leaf extract dose of 100 mg/kg and 150 mg/kg affected the fasting blood glucose and pancreatic beta cell number which were exposed to a high-fat diet and streptozotocin.


In vivo study on effect of soursop leaf extract on cancer
Subject Mice (n=20)
Duration of the study 8 weeks
Dosage 0, 100, 150 and 200 mg/kg /day
  1. Negative control (C-)
  2. Positive control (C+)
  3. Treatment 1 (100mg/kg)
  4. Treatment 2 (150mg/kg)
  5. Treatment 3 (200mg/kg)
Parameters analysed Oxidative enzyme level & tissue analysis
Soursop leaf extract may be used to treat breast cancer via antioxidant activity.
Visible benefits
Soursop leaves extract with dose of 200 mg/kg increased the levels of SOD, and decreased the levels of MDA in mammary tissue and improved the cells of breast cancer back to normal.

Relieve Stress

In vivo study on effect of soursop leaf extract on stress
Subject Healthy rats (n=36)
Duration of the study 65 days
Dosage 100, 200, 300 mg/kg /day
  1. Negative control (No caffeine + No soursop)
  2. Positive control (Caffeine)
  3. Treatment 1 (Caffeine + 100mg/kg)
  4. Treatment 2 (Caffeine + 200mg/kg)
  5. Treatment 3 (Caffeine + 300mg/kg)
Parameters analysed Oxidative stress markers level
Soursop leaf intervention can help in reducing daily stress.

Visible benefits

  • A statistically significant decrease in the plasma level of superoxide dismutase (SOD), catalase activity (CAT) and glutathione peroxidase (GPx) when treated with caffeine compared to control.
  • However, soursop leaf tea mitigated the oxidative stress caused by caffeine.

Standardized Pure 100:1 Annona Muricata Soursop Leaf Powder Extract

  • Pure 100:1 Soursop Leaf Annona muricata Extract
  • 0.01-0.02% Acetogenins (Bio-active Phytonutrient)
  • Ultrasonic hot water extraction
  • Scientifically tested
  • Healthy kidney function
  • May help fight infection
  • May control inflammation
  • May help treat insomnia
  • Boost immune system
  • High in antioxidant