Knowledge: Peach (Prunus persica L.)

Peach (Prunus persica L.)

Peach (Prunus persica L.) belongs to the Rosaceae family, originated in China. Different varieties of peaches are highly consumed worldwide. It is commercially grown in many countries at a fair range of different climate conditions and types of soils.

Peach fruits are a drupe composed of skin (epidermis), flesh (mesocarp), and stone (endocarp) enclosing the seed. Ripening peach can be clingstone (flesh adhering to the stone) or freestone (flesh separating from the stone); melting (flesh quickly softening) or non-melting (flesh remaining firm). The flesh can be white, yellow or red according to mesocarp colour.

Peaches present many secondary metabolites, such as phenolic compounds, carotenoids and tocopherols that present important biological actions and are associated with disease prevention. Two main groups of phenolic compounds present in peach have different structural characteristics – NonFlavonoids, which include phenolic acids; and Flavonoids, which include flavonols, flavan-3-ols and anthocyanins.

Figure 1: Phenolic acids reported in peach
Figure 2: Flavanols reported in peach
Figure 3: Flavan-3-ols reported in peach
Figure 4: Anthocyanins reported in peach

We provide practical, easy & consistent on food processing application.
Fresh natural flavor extract powder for Bakery & Beverage.

Vegan, Non-GMO, No Fillers, No Flavors, No Additives, No Artificial Colors, Soy and Gluten Free, Lab Tested for Authentic & Active Compound

High Standard Product Quality Control​



In vivo study was conducted to investigate tumor growth inhibition and anti-metastatic effects of peach phenolics
Subject Female athymic nude mice implanted with MDA-MB-435 human breast cancer cells. 10 days after tumor implantation, animals were divided into equal groups (5 per group)
Duration 24 days
Group and Dosage Xenograft group
Group 1 – received 100µL 10% saline solution (xenografted control)
Group 2 – received Peach phenolics (0.2 to 1.6 mg chlorogenic acid equivalents (CAE)/day dissolved in saline solution) by oral gavageNon-Xenografted group
Group 1 – received 0.8 CAE/day
Group 2 – received 1.6 mg CAE/day
Parameters analyzed
  • Effects on body weight, tumor volume and tumor weight in xenograft and non-xenografted model
  • mRNA analyses for gene expression of matrix metalloproteinases (MMPs) in tumor tissues
  • Gene expression of human-specific β-2 globulin (hβ2G) in the lungs of xenografted and non-xenografted
Outcomes Visible benefits

  • Peach phenolics in a range of 0.2 – 1.6 mg CAE/day did not exert adverse effects on body weight gain and appearance of major organs including liver and kidney in the non-xenografted controls
  • Treatment with peach phenolics at a dose 0.8 to 1.6 mg CAE/day inhibited the tumor growth (p < 0.05) of the xenografted animals after 12 days compared to the xenografted control group
  • The final weights of the tumors were apparently lower (76.6% and 76.4% of xenografted control, respectively) in mice treated with 0.8 and 1.6 mg CAE/day of peach phenolics
  • Treatment with peach phenolics (1.6 mg CAE/day) inhibited gene expression of MMP-2, MMP-13, and MMP-3 down to 0.68-, 0.57-, and 0.54- fold of the xenografted controls
  • hβ2G gene expression in the lungs of peach phenolics-treated mice, 0.8 and 1.6 mg CAE/day, were 7.5- and 5.4- fold greater than the non-xenografted control, respectively; whereas in the xenografted controls, hβ2G gene expression was 25- fold greater than the non-xenografted controls
  • Tumor growth and lung metastasis were inhibited in vivo by peach polyphenolics in a dose range of 0.8 – 1.6 mg/day and these effects were mediated by inhibition of metalloproteinases gene expression.
Functions Peach phenolics inhibit tumor growth and protect against angiogenesis and metastasis.

Figure 5: Anti-tumorigenic activity of peach phenolics in xenografted nude mice. Effects on body weight (A), tumor volume (B) and tumor weight (C)

Figure 6: mRNA levels of metalloproteinases (MMPs) MMP-1, MMP-2, MMP13, and MMP-3 in peach phenolics-treated mice (0.8 – 1.6 mg CAE/day)

Figure 7: Expression of human-specific hβ2G in the lungs of xenografted and non-xenografted control mice treated with peach phenolics (0.8 – 1.6 CAE/day)

Materials Lyophilized samples of:

  • Fresh peach pulp (FPP)
  • Peach peel
  • Preserve peach pulp (PPP)
  • Preserve syrup
Subject Liver, kidney and brain cortex tissue slices from rats were pre-incubated with peach samples, after that incubated with a ferrous sulphate and hydrogen peroxide (FeSO4 /H2O2) system in order to induce cytotoxicity, producing hydroxyl radicals.


Parameter Analyzed Result
In Vitro Study Total reactive antioxidant potential (TRAP assay)
indicates the quantity of antioxidants present in the plant extract
The peel suspension showed the highest antioxidant activity, followed by the FPP suspension. PPP had no significant effect
Total antioxidant reactivity (TAR)
indicates antioxidant effectiveness
Peel and FPP had the highest TAR indexes, compared to PPP and syrup.
Ex Vivo Study Level of lactate dehydrogenase (LDH)
indicates cytotoxicity
  • In kidneys, FPP, peel and PPP prevented the increase in LDH caused by the hydroxyl generating system, indicating a protective effect.
  • In liver, FPP and peel had a significant protective effect.
  • In brain cortex, only FPP had a significant effect on LDH activity
Antioxidant enzymes – Superoxide Dismutase (SOD) and Catalase (CAT)
monitor oxidative stress
  • In kidney and brain cortex slices, pre-incubation with FPP and peel significantly inhibited the activation of CAT by incubation with the FeSO4/H2O2 system.
  • In liver, only FPP was able to inhibit the CAT activities. SOD activation induced by FeSO4/H2O2 system was prevented in kidney by FPP, peel and PPP.
  • In brain cortex, inhibition of SOD activities was observed with FPP and peel as in liver. Since SOD and CAT activities are generally enhanced in conditions of increased substrate production, these results altogether suggest that the pretreatments carried out here conferred antioxidant protection to kidney and brain cortex
Quantification of total reduced sulfhydryl (SH) groups
oxidative status of thiol groups
  • Protein SH oxidation was not prevented statically by any pre-treatment
  • In liver, FPP group had no difference to control group indicating a possible protection
Formation of carbonyl groups
oxidative damage to proteins
  • FPP protected all tissues against the reaction with carbonyl groups.
  • PPP was able to prevent carbonyl formation in kidney
Formation of thiobarbituric acid reactive species (TBARS)
oxidative damage on lipids
  • Pre-treatment with peel significantly reduced
  • Increase in TBARS formation in all tissue slice samples. In brain cortex slices, FPP also had a protective effect.
Fresh peach pulp and oeel demonstrated high antioxidant effects preventing against cytotoxicity, oxidative stress and oxidative damage towards lipids and proteins.Peach peels presented antioxidant activity mainly in the lipid fraction while Fresh peach pulp had a major antioxidant effect to soluble protein fractions suggest that different secondary compounds present in distinct parts of the fruit (i.e., pulp and peel) are responsible for these effects.

Anti Glycation

In vitro study
Parameter Isolated albumin subjected to a glycation protocol through incubation with glucose and fructose during 21 days
Result Albumin glycation was significantly inhibited by peel and FPP by 40% at different doses. PPP only by 10%, while the syrup alone, probably due to its high sucrose content (more than 20%), enhanced glycation by 30%.
Function Fresh peach pulp and peel reduce effect of protein glycation


Ex vitro study
Parameter Quantification of tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β)
  • In kidney tissue, the FPP, peel and PPP prevented the release of TNF-α and IL-1β.
  • In the liver, only the peel caused a similar effect, preventing the increase of TNF-α and IL-1β release caused by the pro-oxidant insult. FPP also inhibited the release of TNF-α in brain cortex
Function Fresh peach pulp and peel showed anti-inflammatory effect

Figure 8: Antioxidant and anti-glycation profile
(A) Total reactive antioxidant potential (TRAP assay)
(B) Kinetics of chemiluminescence intensity
(C) TAR index
(D) Percentage of in vitro albumin glycation

Figure 9: Effects of FPP, peel, PPP and syrup on cytotoxicity and antioxidant enzyme activities in tissue slices subjected to oxidative stress
(A) LDH activity in the incubation medium was analyzed as a parameter for cytotoxicity (cell rupture).
(B) CAT and (C) SOD activities were assessed in homogenized tissue slices of kidney.
(D), (E), (F) represent respectively the same protocols to liver homogenate, and (G), (H), and (I) to brain cortex.

Figure 10: Effects of FPP, peel, PPP and syrup on biomolecule oxidative damage. Tissues were homogenized and analyzed for (A), (B), (C) protein carbonylation, reduced sulphydryl content and TBARS content in kidney. The same assays were conducted to liver (D), (E), (F) and brain cortex (G), (H), (I).

Figure 11: Effects of FPP, peel, PPP and syrup on interleukin release. (A) TNF-α of kidney, (C) liver and (E) brain cortex was quantified. IL1-β levels in (B) kidney, (D) liver and (F) brain cortex was evaluated.


  1. Catarina Bento, Ana C. Gonçalves, Branca Silva, Luís R. Silva. (2020) Peach (Prunus Persica): Phytochemicals and Health Benefits. Food Reviews International, 38 (8), 1703-1734
  2. Mokrani, A, Krisa, S, Cluzet, S, Costa, G.D, Temsamani, H., Renouf, E., Mérillon, J.M., Madani, K., Mesnil, M., Monvoisin, A. et al. (2016) Phenolic contents and bioactive potential of peach fruit extracts. Food Chemistry. 202, 212-220.
    DOI: 10.1016/j.foodchem.2015.12.026
  3. Zhao, X.; Zhang, W.; Yin, X.; Su, M.; Sun, C.; Li, X.; Chen, K. (2015) Phenolic Composition and Antioxidant Properties of Different Peach [Prunus Persica (L.) batsch] Cultivars in China. . Int. J. Mol. Sci., 16(3), 5762–5778.
    DOI: 10.3390/ijms16035762.
  4. Dabbou S, Maatallah S, Castagna A, Guizani M, Sghaeir W, Hajlaui H, Ranieri A. (2017) Carotenoids, phenolic profile, mineral content and antioxidant properties in flesh and peel of Prunus persica fruits during two maturation stages. Plant Foods for Human Nutrition, 72, 103-110
    DOI: 10.1007/s11130-016-0585-y
  5. G. Noratto, W. Porter, D. Byrne, and L. Cisneros-Zevallos (2014) Polyphenolics from peach (Prunus persica var. Rich Lady) inhibit tumor growth and metastasis of MDA-MB-435 breast cancer cells in vivo. The Journal of Nutritional Biochemistry, 25 (7): 796–800
    DOI: 10.1016/j.jnutbio.2014.03.001
  6. Gasparotto J, Somensi N, Bortolin RC, et al. (2014) Effects of different products of peach (Prunus persica L. Batsch) from a variety developed in southern Brazil on oxidative stress and inflammatory parameters in vitro and ex vivo. Journal of Clinical Biochemistry and Nutrition, 55(2):110-119
    DOI: 10.3164/jcbn.13-97
Prunus persica extract

Peach (Prunus persica) Standardized Extract Powder

  • Pure 20:1 Peach Prunus persica Extract
  • Good for the eyes
  • Healthy for heart
  • Healthy for skin
  • Help in weight loss
  • Improve digestion
  • May detoxify your system
  • May help reduce stress
  • Rich in antioxidant
  • Ultrasonic hot water/solvent extraction