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STANDARDIZED Senna leaf Extract
The genus senna comprising of 500 species of which 26 species of genus cassia have been reported to contain anthracene derivatives either in the free form or glycosides. Out of these, Cassia angustifolia (Indian senna) and Cassia acutifolia (Alexandrian senna) are official in different pharmacopoeias, because of laxative activity and also because they are available in large quantities.
The maximum daily dose to treat constipation is 15 to 30 mg sennosides. However the correct individual dose is the smallest required producing a comfortable soft-formed motion. The dosage for senna is about 500 mg to 2 gm of the powder of leaf or pod.
Pure Senna Leaf Senna alexandrina Extract must have Sennosides!
- No Fillers
- No Flavors
- No Additives
- No Preservatives
- No Artificial Colors
- Soy and Gluten Free
- Lab Tested for Authentic & Active Compound
- Origin from Malaysia Farm
BIONUTRICIA Senna alexandrina Senna Leaf Extract
|Certification||Registered with the Ministry of Health, Halal Tested||Not registered & certified|
|Raw Ingredients||Senna alexandrina Senna Leaf Extract from Malaysia||Very little / no raw ingredients; Use non-Senna Leaf materials|
|Process||Extracted through R.O. water & Ultra-sonic; Full bio-active ingredients||Grinded plant powder; Extracted through ethanol process|
|Active Compound||Tested with high amount of Sennosides||Not Tested|
|Formulation||Only Senna alexandrina Senna Leaf- which is proven safe and effective||Combination of other ingredients (effectiveness & safety is not proven); Added with prohibited drugs|
|Label||Transparent, standardized Senna alexandrina Senna Leaf Extract (>10%) Sennosides (Bioactive Phytochemicals)||Misleading claim (quantity), incorrect amount of Senna Leaf extract, mostly filler ingredients|
Senna is an anthranoid type stimulating laxative. The laxative effect is due to the action of sennosides and their active metabolite, rhein-anthrone, in the colon. There are two different mechanism of action: 1. An influence on the motility of the large intestine: By the inhibition of water and electrolyte absorption from the large intestine, which increases the volume and pressure of the intestinal contents, resulting in propulsive contractions. 2. An influence on secretion processes: Stimulation of active chloride secretion increases water and electrolyte content of the intestine.
HALAL Certificate & High Standard Product Quality Control
In vivo study on effect of senna extract on chemotherapy-induced constipation
|Duration of the study||6 weeks|
|Groups||(1) Crude fiber|
(2) Senna extract
|Parameters analysed||Abdominal pain and stool properties|
Senna extract 40 mg/kg was effective and safe in treating chemotherapy-induced constipation.
• The effective rate of constipation by taking senna extract was 92.68% and that by the crude fiber diet was 10.93%.
• The occurrence rate of abdominal pain after taking senna was 8.54% and the rate of loose stool was 35.53%.
Relieve Chronic Constipation
In vivo study on effect of senna powder on chronic constipation
|Subject||Participants with chronic constipation (n=48)|
|Duration of the study||4 weeks|
|Dosage||<1g senna powder per day|
|Groups||(1) Placebo (2) Treatment|
|Parameters analysed||Questionnaire on severity of constipation and defecation difficulties|
|Function Senna can be used to treat individuals with chronic functional constipation.||Visible benefits • Defecation frequency increased by 2.7 times in treatment group but only 1.3 times in placebo. • Defecation difficulties have been improved in treatment group.|
In vivo study on effect of senna extract on toxicity
|Duration of the study||4 weeks|
|Dosage||Senna extract 100mg/kg|
|Groups||(1) Control (2) SAE (100 mg/kg) (3) CdCl2 (0.6 mg/kg) (4) SAE + CdCl2|
|Parameters analysed||Liver function marker, oxidative stress marker and antioxidant enzyme activity in serum and liver|
|Function SAE can be used as a promising protective agent against hepatotoxicity.||Visible benefits • SAE administration before CdCl2 exposure decreased cadmium deposition in liver tissue and the blood liver function indicators. • SAE pre-treatment prevented oxidative, inflammatory, and apoptotic reactions and decreased histological alterations to the liver caused by CdCl2 exposure.|
Standardized Pure Senna alexandrina Senna Leaf Extract
- Pure 100:1 Senna alexandrina Senna Leaf Extract
- (>10%) Sennosides (Bioactive Phytochemicals)
- Relieve constipation
- Promote intestinal health
- Natural colon cleanser
- Improve digestive function
- Help manage weight
- Ultrasonic hot water extraction
- Scientifically tested