Pegaga Extract

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Standardized Pegaga Extract

Centella asiatica

Centella asiatica (Gotu kola, pegaga, 积雪草, 崩大碗) is an imperative herb in Traditional Chinese and Ayurvedic medicine. It is a tropical plant native to Southeast Asian countries such as India, Sri Lanka, China, Indonesia, and Malaysia as well as South Africa and Madagascar. This plant grows wild in damp, shady places up to 7000 ft. and can be commonly seen along banks of rivers, streams, ponds, and irrigated fields.

Its leaves are used for medicinal purposes and provide important health benefits related to healthy veins and blood vessels, to treat skin problems, to heal wounds, help with better memory and improve brain function. 
Due to its various medicinal and nutritional properties, it is used as a traditional medicine, as a leafy vegetable, and as a beverage in many countries. The nutritional value of C. asiatica is mainly due to its richness in carotenoids and vitamins C and B complex, potassium and calcium.
In Malaysia and Indonesia, C. asiatica is commonly eaten fresh as vegetable (“ulam” and salad) especially by the local Malay and Javanese populations. Besides eaten raw, it is also cooked as a part of a soup or as a main vegetable. Due to its mild bitterness, it is always cooked and served with the addition of coconut milk and/or shredded coconut and sometimes sweet potatoes and potatoes are added. It is used as a health tonic and processed into cordial drinks and is available at some markets as a ready-made juice. C. asiatica herbal tea is made by adding a cup of boiled water over either dried or fresh C. asiatica plant tissues, letting it brew a few minutes before drinking.
C. asiatica leaves contains triterpenes and their derivative molecules. Most important constituents are asiatic acid, asiaticoside, madecassic acids, and madecosside.

High Standard Product Quality Control​

Our Standardized Pegaga extracts are tested by Sirim which contain high amount of active compounds.

HEALTH BENEFITS

Relieve Pain

In vivo study on pegaga extract on pain and inflammation

Subject Adult male mice and rats (n=60)
Duration of the study 4 hr
Dosage • Water extract of CA (2, 4, 10 mg/kg)
• Water extract of CA (10, 30, 100, 300 mg/kg)
Groups • Negative control (saline)
• Control (paracetamol alone)
• Treatment group
• Positive control (aspirin, morphine, mefenamic acid)
Parameters analysed Malondialdehyde (MDA) -Serum vitamin C
• Writhing test (abdominal constriction test)
• Hot plate test
• Paw volume
Function
CA extract possesses centrally and peripherally mediated anti-nociceptive properties and anti-inflammatory activity.
Visible benefits
• CA extract (100 and 300 mg/kg) reduced writhing by 64% and 85% respectively. Inhibition at 300 mg/kg, was similar to the control drug aspirin.
• Intraperitoneal administration of the extract prolonged the response latency in the hot plate test.
• The anti-inflammatory activity of CA (4 mg/kg) was similar to mefenamic acid.

Wound Healing

In vivo study on effect of pegaga extract on wound healing

Subject Rats (n=24) divided into incision, excision, and dead space wounds models
Duration of the study 10 days
Dosage 800 mg/kg orally
Groups Group 1: Wounded and treated with normal saline
Group 2: Wounded and treated with extract.
Group 3: Wounded and treated with dexamethasone
Group 4: Wounded and treated with dexamethasone and extract
Parameters analysed Malondialdehyde (MDA) -Serum vitamin C • Breaking strength
• Epithelization period
• Weight of dried granulation tissue
• Hydroxyproline level
Function • Triterpenes from C. asiatica stimulate extracellular matrix accumulation and stimulate glycosaminoglycans synthesis in wounds.
• Asiatic acid is responsible for the collagen synthesis stimulation.
Visible benefits • Extract–treated animals showed significantly increased levels of hydroxyproline content (which is a reflection of increased collagen content), granulation tissue weight (wet and dry), and tissue breaking strength
• Intraperitoneal administration of the extract prolonged the response latency in the hot plate test. • CA leaves extract reversed anti-healing effect of dexamethasone in all wound models.

Oxidative Stress

In vivo study on effect of pegaga extract on oxidative stress

SubjectAdult rats (n=70)
Duration of the study25 weeks
Dosage• 0.3% CA extract
• 5% CA powder
GroupsGroup 1: normal diet
Group 2: normal diet + 0.1% H2O2 in drinking water
Group 3: normal diet + 0.1% H2O2 + 0.3% CA extract
Group 4: normal diet + 0.1% H2O2 + 5% CA powder
Group 5: normal diet + 0.1% H2O2 + 0.3% α-tocopherol
Parameters analysed• Lipid peroxidation
• Free radical scavenging enzymes: superoxide dismutase (SOD)
• Catalase
Function
CA extract and powder may ameliorate H2O2-induced oxidative stress by decreasing lipid peroxidation via alteration of the antioxidant defence system of the host.
Visible benefits
• Administration of H2O2 (0.1%) in drinking water increased the malonaldehyde levels in erythrocytes but rats receiving CA extract, powder and α-tocopherol had lower MDA levels indicating reduced lipid peroxidation.
• The decrease in the activity of SOD in CA- and α-tocopherol treated rats suggested a lower requirement for the enzyme and this indicates the protective effect of the plant in combating oxidative stress undergone by the rats.

Anti-aging in brain

In vivo study on effect of pegaga extract on age-related neurological disease

Subject Young and aged male rats (n=24)
Duration of the study 60 days
Dosage 300 mg/kg daily
Groups Group 1: Young rats (saline) Group 2: Young rats (CA treated) Group 3: Aged rats (saline) Group 4: Aged rats (CA treated)
Parameters analysed • Protein carbonyl content (PCO) • Lipid peroxidation (LPO) • Superoxide dismutase (SOD) activity • Catalase activity • Glutathione peroxidase (GSH-Px) activity • Reduced glutathione (GSH) level -Vitamin C, vitamin E and protein level in rat brain regions (cortex, hypothalamus, striatum, cerebellum and hippocampus)
Function
CA acting as a potent antioxidant exerted significant neuroprotective effect and proved efficacious in protecting brain against age-related oxidative damage.
Visible benefits • Aged rats elicited a significant decline in the antioxidant status and increased the LPO and PCO compared to young rats in all five regions tested.
• Supplementation of CA was effective in reducing brain regional LPO and PCO levels and in increasing the enzymatic and non-enzymatic antioxidant status.
• Treatment with CA enhanced the status of both vitamin C and vitamin E in aged rat brain regions via improvement of the GSH status.

Anti-diabetes

In vivo study on effect of pegaga extract on diabetes

Subject Obese diabetic rats (n=47)
Duration of the study 4 weeks
Dosage 300 mg/kg daily
Groups Group 1: Normal diet Group 2: Obese (ob) Group 3: Obese-diabetic (obdb) Group 4: Obdb treated with CA extract Group 5: Obdb treated with metformin (MTF)
Parameters analysed • Blood glucose, insulin, cholesterol, LDL and HDL levels • Metabolite analysis of urine and serum samples
Function CA exerted both anti-hyperglycemic and anti-hyperlipidemic effects by increasing the insulin secretion and ameliorating the metabolic pathways affected in the diabetic individuals. Visible benefits • A long-term treatment of obese diabetic rats with CA extract reversed the glucose and lipid levels, as well as the tricarboxylic acid cycle and amino acid metabolic disorders, back towards normal states. • Biochemical analysis showed an increase of insulin production in diabetic rats upon treatment of CA extract.