Misai Kucing / Cats Whiskers (Orthosiphon Aristatus / Orthosiphon Stamineus)

Cats Whiskers / Misai Kuching (Orthosiphon Aristatus / Orthosiphon Stamineus)

Cats Whiskers (Orthosiphon aristatus / Orthosiphon stamineus) is a medicinal herb found mainly throughout southern China, the Indian Subcontinent, South East Asia and tropical Queensland. It is known as Kumis Kucing in Indonesia and Misai Kucing in Malaysia. The plant has white or purple color flowers giving the impression of cat’s whiskers. It has lots of leaves and the leaves are widely used for herbal teas (Java Tea) in South-East Asia.

Traditionally, the infusion of dried leaves is used for treating rheumatic pain and coughs. The fresh leaves are used to prepare strong decoction for treating a wide variety of ailments, such as gout, renal inflammation, kidney stones, and hypertension due to the diuretic action. It is also consumed as general tonic for detoxification and relieving tiredness.

● Pure 20:1 Pineapple Extract
● 1-3% Bromelain (Bioactive Phytochemicals)
● Vegan ● Non-GMO
● No Fillers ● No Flavors
● No Additives ● No Preservatives
● No Artificial Colors ● Soy and Gluten-Free
● Lab Tested for Authentic & Active Compound

Pure Misai Kucing Orthosiphon Aristatus Extract must have Rosmarinic acid & Sinensetin!

Without Rosmarinic acid & Sinensetin, its not Misai Kucing Orthosiphon Aristatus! 0.3-0.8% Rosmarinic acid & Sinensetin (Bioactive Phytochemicals)

No harm/chemicals/preservative, just harmony, manufactured naturally

Healthy kidney function
Improve urinary tract health
Maintain optimal liver function
Relieve gout symptoms
Cholesterol and blood pressure control

	BIONUTRICIA Orthosiphon aristatus Misai Kucing Extract	BRAND X
Certification	Registered with the Ministry of Health, Halal Tested	Not registered & certified
Raw Ingredients	Orthosiphon aristatus Misai Kucing from Malaysia	Very little / no raw ingredients; Use non-Misai Kucing materials
Process	Extracted through R.O. water & Ultra-sonic; Full bio-active ingredients	Grinded plant powder; Extracted through ethanol process
Active Compound	Tested with high amount of Rosmarinic acid & Sinensetin	Not Tested
Formulation	Only Misai Kucing – which is proven safe and effective	Combination of other ingredients (effectiveness & safety is not proven); Added with prohibited drugs
Label	Transparent, standardized Misai Kucing extract with 0.3-0.8% Rosmarinic acid & Sinensetin	Misleading claim (quantity), incorrect amount of Misai Kucing extract, mostly filler ingredients

A wide range of flavonoids were detected in various tissues of Orthosiphon stamineus such as rosmarinic acid, caffeic acid, quercetin, eupatorin,and sinensetin.

Halal Certificate & High Standard Product Quality Control

HEALTH BENEFITS

Kidney Healthy

In vivo study on effect of Misai Kucing extract on kidney
Subject	Male rats (n=30)
Duration of the study	19 days
Dosage	100-200 mg/kg/oral
Groups	Vehicle control 80 mg/kg/day C21H43N5O7 for 9 days to induce nephrosis C21H43N5O7 + 100 mg/kg extracts (10th to 19th day) C21H43N5O7 + 200 mg/kg extracts 200 mg/kg extracts only
Parameters analysed	Body weight, blood urea, serum creatinine, total protein and glutathione levels
Function Effective dosage of 200mg/kg can reverse the neprotic damage caused by drug.	Visible benefits The increased levels of serum creatinine, blood urea, urinary protein and extent of renal damage were decreased by the Misai Kucing extract at both dose levels. No toxicity was seen when 200mg/kg extracts was administrated.

Anti-diabetes

In vivo study on effect of Misai Kucing extract on diabetes
Subject	Male rats (n=30)
Duration of the study	14 days
Dosage	0.2, 0.5, 1 g/kg/oral water extract
Groups	Normal/diabetic rats Distilled water (negative control) 0.2 g/kg extract 0.5 g/kg extract 1 g/kg extract 5 mg/kg C₂₃H₂₈ClN₃O₅S (positive control)
Parameters analysed	Fasting plasma glucose, blood urea nitrogen (BUN), alanine aminotransferase (ALT), asparate aminotransferase (AST), cholesterol, triglycerides and high-density lipoprotein (HDL) cholesterol, plasma lipid profiles and blood chemistry
Function Misai Kucing aqueous extract is effective for alleviating hyperglycemia and improving lipid profile in diabetic individuals. It has direct stimulatory effect on in su lin secretion from the pancreatic beta cells.	Visible benefits The extract (0.2–1.0 g/kg) significantly decreased plasma glucose concentration in both normal and diabetic rats. The extract at 1.0 g/kg was most effective in decreasing plasma glucose concentrations and comparable to standard drug. Plasma HDL-cholesterol concentration was significantly increased in diabetic rats treated with the extract.

Anti-aging In Brain

In vivo study on effect of Misai Kucing extract on brain function
Subject	Male rats (n=90)
Duration of the study	2 hours
Dosage	Misai Kucing extract (60, 120, 200, 300, and 600 mg/kg)
Groups	Vehicle control Positive control: G. biloba extract (120 mg/kg) 0.5 g/kg extract Positive control: drug C₂₄H₂₉NO₃ (3 mg/kg)
Parameters analysed	Social recognition test
Function Extract of Misai Kucing leaves improves memory by reversing age-related deficits in short-term social memory. The extract might act at adenosine bioactivity site in the restoration of memory.	Visible benefits Misai Kucing extract showed significant change in recognition index at 300 mg/kg and 600 mg/kg p.o and 120 mg/kg i.p., respectively, compared to the vehicle control.

Anti-inflammation

In vivo study on effect of Misai Kucing extract on inflammation
Subject	Arthritis rats (n=20)
Duration of the study	21 days
Dosage	Misai Kucing extract (200, 400 mg/kg) daily
Groups	Negative control Positive control: Diclofenac sodium Treatment group
Parameters analysed	Paw edema and granulation, X-ray radiography, fluorescence molecular tomography (FMT), and histological evaluation
Function The anti-arthritic properties of Misai Kucing could be beneficial for prevention and management of rheumatoid arthritis and other chronic inflammatory disorders.	Visible benefits Treatment with Misai Kucing extract resulted in dose-dependent inhibition of paw edema in acute and chronic models of inflammation. It significantly suppressed FCA-induced paw edema as well as the serum levels of TNF-α and IL-1. The extract improved joint integrity and recover bones from degeneration and osteoporotic lesions. It also showed protection of cartilage and soft tissue.

Natural Diuretic

In vivo study on effect of Misai Kucing extract on diuretic and hypouricemic activity
Subject	Rats (n=36)
Duration of the study	6 hours
Dosage	0.25-2 g/kg
Groups	Negative control Positive control Treatment group
Parameters analysed	pH, cumulative urinary volume and cumulative urinary excretion of sodium and potassium, serum urate level
Function Polar components such as rosmarinic acid and sinensetin, eupatorin, sinensetin, rutin, and caffeic acid in the extract contribute to the diuretic and hypouremic activity.	Visible benefits Extract at 2 g/kg increased sodium and potassium excretion, and the effect was similar to the control, C₇H₈ClN₃O₄S₂. Oral administration of 0.5, 1.0 and 2.0 g/kg of extracts significantly reduced serum urate level of hyperuricemic rats at 6th hour, which is comparable to the standard C₅H₄N₄O.

Toxin Free

In vivo study on effect of Misai Kucing extract on toxin
Subject	Rats (n=18)
Duration of the study	7 days
Dosage	1.1 g/kg
Groups	Negative control Treatment group
Parameters analysed	HPLC-MS to detect changes in metabolites Analysis of urine and serum
Function Oral OS extract administration may improve basic metabolite levels and immunity in humans by improving the detoxification ability of the body through an “antidote” mechanism.	Visible benefits The oral administration of OS extract mainly affected the citrate cycle (TCA cycle), taurine and hypotaurine metabolism, tyrosine metabolism, and sphingolipid metabolism pathways.