Garcinia mangostana Extract

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STANDARDIZED Mangosteen peel extract

Garcinia mangostana L.

​Mangosteen, Garcinia mangostana L., is known as the “Queen of fruits” in Asia and can be cultivated in the tropical rainforest such as Malaysia, Indonesia, and Thailand. The purple ripe fruits consist of 6-8 seeds, and have a white and juicy pulp. Normally, people just eat the sweet pulp and throw away the purple peel.

However, studies found out that mangosteen peel is also useful, and the peel even contains more antioxidant than the pulp. Mangosteen extracts and purified constituents have been subjected to a wide array of biological tests particularly to infectious diseases, cancer chemotherapy and cancer chemoprevention, diabetes, and neurological conditions.
Pure Mangosteen Peel Garcinia mangostana Extract must have Xanthone!
Without Xanthone, its not Mangosteen Peel Garcinia mangostana! 6-10% Xanthone (Bioactive Phytochemicals) No harm/chemicals/preservative, just harmony, manufactured naturally
  • Vegan
  • Non-GMO
  • No Fillers
  • No Flavors
  • No Additives
  • No Preservatives
  • No Artificial Colors
  • Soy and Gluten Free
  • Lab Tested for Authentic & Active Compound
  • Origin from Malaysia Borneo Forest
  • Reduce inflammation
  • Healthy weight management
  • Blood sugar control
  • Strengthen immunity system
  • Improve skin health
 

BIONUTRICIA Garcinia mangostana Mangosteen Peel Extract

BRAND X

CertificationRegistered with the Ministry of Health, Halal TestedNot registered & certified
Raw IngredientsGarcinia mangostana Mangosteen Peel from MalaysiaVery little / no raw ingredients; Use non-Mangosteen Peel materials
ProcessExtracted through R.O. water & Ultra-sonic; Full bio-active ingredientsGrinded peel powder; Extracted through ethanol process
Active CompoundTested with high amount of XanthoneNot Tested
FormulationOnly Mangosteen Peel – which is proven safe and effectiveCombination of other ingredients (effectiveness & safety is not proven); Added with prohibited drugs
LabelTransparent, standardized Mangosteen Peel extract with 6-10% XanthoneMisleading claim (quantity), incorrect amount of Mangosteen Peel extract, mostly filler ingredients

Compounds isolated from the fruit peel of mangosteen contain abundant xanthones, for example: α-mangostin, β-mangostin, γ-mangostin, gartanin, 8-deoxygartanin, and mangostanol. α-mangostin represents the majority of the clinical benefits of this plant, therefore determination of the concentration of α-mangostin as a chemical marker to quality control of G. mangostana and its products is usually done and marked in labels. Nowadays, mangosteen extract is also popularly applied to cosmetic and pharmaceutical products.

High Standard Product Quality Control

HEALTH BENEFITS

Anti-tumor

In vivo & in vitro study on effect of Mangosteen peel extract on tumor

SubjectCancerous female mice (n=30)
Duration of the study6 weeks
DosageXanthones extract (10mg/kg, 20mg/kg/day)
Groups• Negative control
• Treatment group
Parameters analysedSurvival rate, tumor growth, histopathologic and mechanism study
Function
LG extract has both hypoglycemic and hypolipidemic effects.
Visible benefits
• 20 mg/kg of extract resulted in prolonged survival rates and increased inhibition of tumor growth and lymph node metastasis.
• The extract elevated apoptotic cell death and increased expression of active caspase-3 and -9 of cancer cells.

Anti-cancer

In vivo & in vitro study on effect of Mangosteen peel extract on colon cancer

SubjectNude mice (n=24)
Duration of the study20 days
Dosage0.25% and 0.5% extract
Groups• Negative control     • Treatment group
Parameters analysedTumor size, histopathologic and mechanism study
Function
α-mangostin and the G. mangostana xanthones are potential anti-colon cancer candidate.
Visible benefits
• The xanthone extract has cytotoxicity comparable to the drug and 2 times higher selectivity towards the colon cancer cells compared to normal cells.
• The extract and α-mangostin inhibited 3 key steps in tumor metastasis including the cell migration, cell invasion and clonogenicity.

Anti-inflammation

In vivo study on effect of Mangosteen peel extract on inflammation

SubjectCarrageenan-induced paw edema in mice (n=12)
Duration of the study6 hours
Dosageα-mangostin (20 mg/kg, p.o.)
Groups• Negative control     • Treatment group     • Positive control
Parameters analysedFoot-pad thickness
Function α-mangostins from G. mangostana is a bioactive substance with anti-inflammatory effects.Visible benefits α-Mangostin exhibited a potent inhibition on paw edema at 3 h, which was more quickly than drug sulindac.

Boost Immune System

In vivo study on effect of Mangosteen peel extract on human immune function

Subject59 healthy human subjects (40–60 years old)
Duration of the study30 days
Dosage59-mL dose per day
Groups• Placebo     • Treatment group
Parameters analysed• Analysis of immune function     • Questionnaire of health status
Function Intake of an antioxidant-rich product significantly enhanced immune responses and improved overall health status.Visible benefits • The treatment group had increased peripheral T-helper cell frequency and reduced serum C-reactive protein concentration.     • Serum IL-1a and IL-1b concentrations in the treatment group were significantly higher than the placebo.      • More participants in the treatment group reported greatly improved overall health status compared with placebo.

Beauty Skin

In vivo study on effect of Mangosteen peel extract on skin

SubjectHealthy women aged 32-48 (n = 11)
Duration of the study12 weeks
DosageMangosteen peel (100 mg/day) in tablet
GroupsTreatment group
Parameters analysed• Skin AGEs by autofluorescence function     • Cell elasticity and moisture content
Function
Intake of the supplement reduces the glycation stress and results in the improvement of skin conditions.
Visible benefits
• Mangosteen peel extract reduced serum pentosidine contents.     • It reduced advanced glycation end-products (AGEs) accumulation in the skin.      • It improved the elasticity and moisture content of the skin.

Bone Health

In vivo study on effect of Mangosteen peel extract on bone

SubjectMice (n =12)
Duration of the study7 days
Dosage20mg/kg, 40mg/kg
Groups• Vehicle control • Negative control • Treatment group
Parameters analysedFemur defect diameter by dental digital radiography
Function Application of a 40 mg/kg dose of mangosteen peel extract promotes bone fracture healing.Visible benefits The femoral defect diameter in 40 mg/kg treated group was less than the negative control.

Standardized Pure 100:1 Garcinia mangostana Mangosteen Peel Powder Extract

  • Pure 100:1 Garcinia Mangostana Mangosteen Peel
  • 6-10% Xanthone (Bio-active Phytonutrient)
  • Ultrasonic solvent extraction
  • Scientifically tested
  • Reduce inflammation
  • Healthy weight management
  • Blood sugar control
  • Strengthen immunity system
  • Improve skin health