Lemongrass (Cymbopogon citratus), a stalky plant with long, thin leaves, is one of the largely cultivated medicinal plants for its essential oils in parts of Asia, Africa and America. It has a fresh, lemony aroma and a citrus flavor. It is a common ingredient in soups, curries, laksa, and tomyam. One of the most popular ways to enjoy lemongrass is in tea.
Anti-inflammatory and Relieve Pain
In vivo study on effect of lemongrass extract on inflammation and pain
|Subject||ALB/c mice (n=20)||Male rats and mice (n=48)|
|Duration of the study||3 days||4 hours|
|Dosage||200 mg/kg body weight||35－140 mg/kg|
|Groups||• Control group • Treatment group||• Negative control • Positive control • Test group|
|Parameters analysed||Macrophages obtained to determine cytokine production||• Paw oedema volume • Analgesic capacity • Histological analysis|
• Lemongrass has anti-inflammatory action by cytokine inhibition. • The polyphenols present in the extract showed a significant contribution for these activities.
|Visible benefits |
• Lemongrass extract inhibited macrophages to produce IL-1β. • Linalool oxide and epoxy-linalool oxide found in the extract possess anti-inflammatory activity.
|Visible benefits |
• Lemongrass extract inhibited oedema by 70.8 and 82.3% in acute inflammatory models while 84% for positive control group • The extract reduced peripheral pain by 57% and 83% for positive control group.
In vivo study on antioxidant activity of lemongrass extract
|Subject||Rats (n=20)||Male rats (n=30)|
|Duration of the study||10 days||60 days|
|Dosage||100 mg/kg body weight||100, 200 mg/kg body weight|
|Groups||• Normal (no treatment) • Control (paracetamol alone) • Treatment group (Extract + paracetamol)||• Normal • Induced cardiotoxicity and untreated • 100 mg/kg body weight • 200 mg/kg body weight • Vitamin E|
|Parameters analysed||Malondialdehyde (MDA) -Serum vitamin C • Catalase activity • Cholesterol • Phospholipids||• Creatine kinase,lactate dehydrogenase (LDH), glutamate oxaloacetate transaminase (GOT) and glutamate pyruvate transaminase(GPT) • Oxidative stress markers like thiobarbituric acid reactive substances (TBARS) and hydroperoxide • Enzymatic antioxidants like superoxide dismutase (SOD), catalase, glutathione peroxidase(GPx) and glutathione-s-transferase (GST) • Non-enzymatic antioxidants like reduced glutathione (GSH), vitamin E and vitamin C.|
|Function • LG extract could protect from drug-induced lipids peroxidation via its antioxidative effects. • LG extract has several phenolic compounds such as isoscoparin, swertiajaponin, isoorientin, chlorogenic acid, and caffeic acid that exert cardioprotective effect.||Visible benefits • Pre-treatment with lemongrass inhibited the elevation of serum levels of MDA and catalase. • The depletion of vitamin C was also prevented. • The extract prevented alteration to membrane lipids by preventing the increase in cholesterol/phospholipid ratio by paracetamol.||Visible benefits • LG pretreatment decreased activity of cardiac markers in serum and increased the same in heart homogenate. • LG decreased the toxic events of lipid peroxidation (TBARS) in both serum and heart tissue, by increasing the level of enzymatic antioxidants and non-enzymatic antioxidants. • The LG extract at a dose of 200 mg/kg b.wt.is cardioprotective and antilipid peroxidative, which is comparable to vitamin E.|
Lemongrass Extract Reduces Body Lipid and Glucose Level
In vivo study on lemongrass extract on lipid profile and glucose level
|Subject||Male rats (n=18)|
|Duration of the study||4 weeks|
|Dosage||1.5 ml/10g BW daily|
|Groups||• Non-diabetic control rats • Non-treated diabetic rats (NTDR) • Treated diabetic rats (TDR)|
|Parameters analysed||Total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL) and glucose levels in blood|
|Function LG extract has both hypoglycemic and hypolipidemic effects.||Visible benefits LG extract reduced BW, blood glucose, TG, TC and LDL levels of diabetic rats and the rats had higher HDL levels compared to the non-treated group.|
In vivo study on lemongrass extract on digestion
|Subject||Male mice (n=32)|
|Duration of the study||1 hour|
|Dosage||200 and 400 mg/kg BW|
|Groups||• Negative control • Positive control|
• 200 mg/kg BW
• 400 mg/kg BW
|Parameters analysed||Gastric damage lesion score|
LG extract can be used to reduce gastric damage and thus potentially be used to treat gastric ulcer, stomach cramping or upset.
• LG pretreatment depicted a higher preventive index in ethanol-(88%) and aspirin-induced (76%) acute ulceration. • The extract protects against aspirin-induced gastric ulcers may be due to enhanced synthesis of prostaglandins, thus improving the microcirculation.
Boosting Red Blood Cell Levels
In vivo study on lemongrass extract on red blood cells
|Subject||55 men and 50 women aged 18-35|
|Duration of the study||30 days|
|Dosage||Infusion of 2, 4, or 8 g of lemongrass leaves once daily|
|Groups||• 2g • 4g • 8g|
|Parameters analysed||Hemoglobin (Hb) concentration, packed cell volume (PCV), red blood cell (RBC) count, mean cell Hb (MCH), mean cell volume (MCV), mean cell Hb concentration (MCHC), total white blood cell (WBC-total) and differentials, and platelets|
|Function It can boost red blood cell production likely due to the presence of some nutritional constituents and its antioxidants.||Visible benefits The LG infusions increased PCV, Hb, and RBC in all subjects, particularly in the subchronic phase (30 days).|