Kacip Fatimah Extract

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Standardized Kacip Fatimah Extract

Labisia pumila

Labisia pumila (Myrsinaceae) is known as Kacip Fatimah in Malaysia and is traditionally used by Malay women. It can be widely found throughout the rain forest of Indochina, particularly in Malaysia. There are three varieties of L. pumila in Malaysia which are var. pumila, var. alata and var. lanceolata. These varieties can be differentiated from each other by their petiole and leaf characteristics. However, var. alata is more frequently used in traditional medicine preparations.

The plants are usually boiled and the water-soluble extract is taken as a drink. A decoction of the herb (the whole plant) is administered 1 to 2 months before childbirth to help strengthen and tone abdominal muscles and the vaginal wall and tissue. In daily practice, it is used for the general well-being and vitality of women, maintaining the figure and appearance, aiding in reducing symptoms related to hormonal imbalance, and increasing libido in women. Its exclusive use by women has led to the belief that it exhibits (phyto)-estrogenic activity, contains compounds with similar chemical structures to estrogens and therefore is able to relieve menopausal symptoms.

Pure Kacip Fatimah Labisia pumila Extract must have Gallic Acid!

Without Gallic Acid, its not Kacip Fatimah Labisia pumila!
0.3-0.8% Gallic Acid (Bioactive Phytochemicals)

  • Vegan
  • Non-GMO
  • No Fillers
  • No Flavors
  • No Additives
  • No Preservatives
  • No Artificial Colors
  • Soy and Gluten Free
  • Lab Tested for Authentic & Active Compound
  • Origin from Malaysia Borneo Forest

Health Benefits

  • Improve female reproductive system
  • Improve well-being and vitality
  • Improve blood circulations and regulate pressure
  • Increase energy and overcomes fatigue
  • May relieve the symptoms of menopause
  • Powerful libido and energy booster
 

BIONUTRICIA Kacip Fatimah Extract

BRAND X

CertificationRegistered with the Ministry of Health, Halal TestedNot registered & certified
Raw IngredientsKacip Fatimah from MalaysiaVery little / no raw ingredients; Use non-Kacip Fatimah materials
ProcessExtracted through R.O. water & Ultra-sonic; Full bio-active ingredientsGrinded root powder; Extracted through ethanol process
Active CompoundTested with high amount of Gallic AcidNot Tested
FormulationOnly Kacip Fatimah – which is proven safe and effectiveCombination of other ingredients (effectiveness & safety is not proven); Added with prohibited drugs
LabelTransparent, standardized KF extract with 0.3-0.8% Gallic AcidMisleading claim (quantity), incorrect amount of Kacip Fatimah extract, mostly filler ingredients

Client Testimonials

Numerous studies have been carried out to identify the bioactive phytochemicals that contribute to the pharmacological properties. The major components of the plant are benzoquinoid compounds contained in the root and leaves, alkenyl resorcinols, and triterpenoid compounds. Flavonoids mainly apigenin, kaempferol, rutin and myricetin identified from L. pumila var alata, along with phenolic contents such as gallic acid, pyrogallol and caffeic acid.

The biomarker for Kacip Fatimah has yet to be commercially available. Therefore, qualitative and quantitative analysis of a series of phenolic compounds can be done to identify the species or variety of Kacip Fatimah.

High Standard Product Quality Control​

Our Standardized Kacip Fatimah extracts are tested by Sirim which contain high amount of active compounds.

Health Benefits

Skin Beauty

In vitro study on effect of Kacip Fatimah extract on skin

SubjectHuman dermal fibroblasts
Duration of the study24, 48, 72 hr
DosageWater extract: 0.001˗0.01%
Groups1. Control
2. +UV
3. Ascorbic acid treated
4. Kacip Fatimah (KF) extract treated
Parameters analysed• Antioxidant assay
• Pro-inflammaotry cytokine (TNF-α) content
• Expression of collagen degrading proteolytic enzyme (MMP-1, MMP-9)
• COX-2 and type 1 pro-collagen levels
Function
• The KF water extract has strong anti-antioxidant activity and it protects dermal fibroblasts from cell death induced by UVB.
• KF extract has tremendous potential as an anti-photoaging cosmetic ingredient.
Visible benefits
• The 50% free radical scavenging activity of KF extract was 0.006% = 156 μM ascorbic acid.
• Treatment with KF extract markedly inhibited the TNF-α production and the expression of COX-2 stimulated by UV irradiation.
• Decreased collagen synthesis of human fibroblasts by UVB was restored back to normal level after treatment with KF extract.
• The enhanced MMP-1 and MMP-9 expression upon UVB irradiation was down regulated by KF extract.

Bone Health

In vivo studies on effect of Kacip Fatimah extract on osteoporosis

Subject Female rats (n=96) Female rats (n=32)
Duration of the study 9 weeks 2 months
Dosage 20mg/kg and 100 mg/kg 17.5 mg/kg daily orally
Groups • Baseline group (BL)
• Sham-operated (Sham)
• Ovariectomised control (OVXC)
• Ovariectomised (OVX) + 64.5 μg/kg Premarin (ERT)
• Ovariectomised + 20 mg/kg LP (LP20)
• Ovariectomised + 100 mg/kg LP (LP100)
• Sham
• OVXC
• ERT
• LP
Parameters analysed Bone oxidative enzyme levels
Malondialdehyde (MDA): product of lipid peroxidation
Glutathione peroxidase (GPx) and superoxide dismutase (SOD): parameters of antioxidant defense system
Bone histomorphometry
Function
• LP supplementation at long term may reduce oxidative stress which in turn may prevent bone loss via its anti-oxidative property.
• LP has potential as an alternative to ERT for prevention of postmenopausal osteoporosis.
Visible benefits
• The SOD and GPx levels of the LP treatment group were higher than the OVX groups.
• Both LP20 and LP100 groups at the 9th week of treatment had lower MDA levels than the ERT group.
Visible benefits
• Histomorphometric analysis revealed osteoporotic changes for the ovariectomized rats.

Weight Loss

In vivo study on effect of Kacip Fatimah extract on body weight

SubjectAdult rats
Duration of the study30 days
Dosage10, 20, 50 mg/kg/day LP water extract
Groups• Sham-operated (Sham)
• OVX+ERT (0.625 mg/kg/day)
• OVX+10 mg/kg/day (LP10)
• OVX+20 mg/kg/day (LP20)
• OVX+50 mg/kg/day (LP50)
Parameters analysed• Plasma adipokines
• mRNA expressions of the adipokines in the adipose tissues
Function
LP exerts uterotrophic effect and regulates body weight gain by modulating secretion of leptin and resistin, and expression of the adipokines in adipose tissues.
Visible benefits
• ERT and LP50 rats showed less weight gain than untreated OVX rats.
• Ovariectomy caused plasma leptin levels to decrease, but LP increased plasma leptin and mRNA expression of leptin to levels higher or comparable to Sham group.
• The elevated plasma resistin concentrations in OVX rats were reduced in rats given ERT and LP extracts.
• The uterus to body weight ratio increased upon treatment with LP.

Heart Health

In vivo studies on effect of Kacip Fatimah extract on cardiovascular disorder

SubjectAdult female rats (n=35)Male rats (n=36) divided to normal and isoproterenol-induced myocardial infarction individual
Duration of the study4 months28 days
DosageWater extract: 17.5mg/kg/dayWater extract: 100, 200, 400 mg/kg orally
Groups• Normal (NOR)
• Ovariectomized (OVXC)
• OVX+KF
• OVX+ERT (120 µg/kg/day)
Group I: normal-control group
Group II: ISO-control group
Group III: Propranolol+ISO
Group IV: 100 mg/kg LP+ISO
Group V: 200 mg/kg LP+ISO
Group VI: 400 mg/kg LP+ISO
Parameters analysedHistological analysis of aorta• Cardiac marker enzyme analysis
• Antioxidant system analysis
• Histology analysis
Function
• LP modulates postmenopausal cardiovascular risks acting similar to estrogen.
• The cardioprotective effects of LP was due to its capability to augment the myocardial antioxidant enzyme levels and enhance the permeability and integrity of the myocardial cell membrane.
Visible benefits
• LP treatment maintained the elastic lamellae architecture of the ovariectomized rat aortae in a manner comparable to normal rats.
• LP acts as phytoestrogens to interact with the estrogen receptor and exert estrogen-like effects.
Visible benefits
• LP pretreated rats showed a dose-dependent decrease in cardiac enzyme activities (cTnI, CK-MB, LDH, ALT and AST) when compared with ISO-control rats.
• LP pretreated rats had rises in the activity of oxidase enzymes (GPx, CAT and SOD) when compared with ISO-control group.
• Pre-treated rats has an improvement in membrane cell integrity compared to untreated rats.

Effects of aqueous extract of L. pumila var. alata on cardiac marker enzymes and antioxidant system in rats.

Data is presented as mean ± SD (n = 6). a Significantly different to isoproterenol-induced (negative control) group at p < 0.05; b Significantly different to normal group at p < 0.05; c Significantly different to propranolol (positive control) group at p < 0.05. Activity is expressed as U/L for serum LDH and AST; IU/L for serum ALT; U/mL for serum SOD, CAT and GPx; U/mg protein for myocardium SOD, CAT and GPx. LDH = Lactate dehydrogenase; AST = Aspartate transaminase; ALT = Alanine transaminase; SOD = Superoxide dismutase; CAT = Catalase; GPx = Glutathione peroxidase.

Effect of the aqueous extracts of Labisia pumila var. alata on histopathological changes, (A) control (normal), (B) ISO (negative control), (C) propranolol 10 mg/kg (positive control), (D): LP 100 mg/kg, (E) LP 200 mg/kg, (F) LP 400 mg/kg. Heart tissues (4 µm thickness) were stained with hematoxylin and eosin and visualized under light microscope at ×10 magnification.

Maintain A Healthy Female Reproductive System

In vivo study on effect of Kacip Fatimah extract on vagina

Subject Ovariectomized adult female rats (n=36)
Duration of the study 7 days
Dosage 100μg/ml, 250μg/ml and 500μg/ml
Groups • Ovariectomized + no intravaginal gel (NG)
• OVX+ERT (0.625 mg/kg/day)
• Ovariectomized + intravaginal plain gel (PG)
• Ovariectomized + intravaginal LP 100 gel
• Ovariectomized + intravaginal LP 250 gel
• Ovariectomized + intravaginal LP 500 gel
• Ovariectomized + intravaginal 0.005% estriol gel (E)
Parameters analysed • Histological analysis
• Protein expression
Function
Intravaginal LP was able to ameliorate features associated with vaginal atrophy (happened in post-menopause) via inducing the increase in the vaginal epithelial cell proliferation, improving the vaginal lubrication, and restoring the vaginal fluid acidity.
Visible benefits
• Thickness of vaginal epithelium increased with increasing intravaginal LP doses.
• LP increased expression and distribution of proliferative protein (PCNA), tight junction protein (occludin), water channel proteins (AQP-1 and AQP-2) and proton extruder protein (V-ATPase A1) in the vagina.
• LP induced desmosome formation and approximation of the intercellular spaces between the vaginal epithelium.

Quantitative measurement of vaginal epithelial thickness.

Groups (n = 6)Epithelial thickness (μm)
NG10.45 ± 2.62
PG10.63 ± 1.21
LP10031.84 ± 5.85*
LP25046.38 ± 3.78*
LP50072.49 ± 16.16*
E97.85 ± 7.35*

Values represent means ± S.E.M for 6 rats per group. *p<0.05 compared to sham and control.

Malaysia Pure 100:1 Kacip Fatimah Powder Extract 0.3-0.8% Gallic Acid

  • Pure 100:1 Kacip Fatima Labisia pumila Extract
  • 0.3-0.8% Gallic Acid (Bio-active Phytonutrient)
  • Ultrasonic hot water extraction
  • Scientifically tested
  • Improve female reproductive system
  • Improve well-being and vitality
  • Improve blood circulations and regulate pressure
  • Increase energy and overcomes fatigue
  • May relieve the symptoms of menopause
  • Powerful libido and energy booster