Soursop Leaf (Annona Muricata)

**Soursop Leaf (Annona muricata)**

The popular fruit tree of Annona muricata (Annonaceae) commonly known as graviola or soursop is commercially cultured in Central and South America and tropical countries. The edible fruit of this small tropical tree is extensively used to produce candy, juice, smoothies, ice-cream and other sweet treats. In addition, this plant is also important due to its various applications in folk medicine. All parts of this plant, including the bark, fruit-seeds, leaves and root are used in natural medicines in the tropics. Traditionally, the leaves are used for cystitis, diabetes, headaches, hypertension, insomnia, liver problems and against skin diseases. Many people also use the soursop leaves to make tea.

Pure Soursop Leaf Annona muricata Extract must have Acetogenins!

Without Acetogenins, its not Soursop Leaf Annona muricata! 0.01-0.02% Acetogenins (Bioactive Phytochemicals)

No harm/chemicals/preservative, just harmony, manufactured naturally

Vegan
Non-GMO
No Fillers
No Flavors
No Additives
No Preservatives
No Artificial Colors
Soy and Gluten Free
Lab Tested for Authentic & Active Compound
Origin from Malaysia Farm

	BIONUTRICIA Annona muricata Soursop Leaf Extract	BRAND X
Certification	Registered with the Ministry of Health, Halal Tested	Not registered & certified
Raw Ingredients	Annona muricata Soursop Leaf Extract from Malaysia	Very little / no raw ingredients; Use non-Soursop Leaf materials
Process	Extracted through R.O. water & Ultra-sonic; Full bio-active ingredients	Grinded plant powder; Extracted through ethanol process
Active Compound	Tested with high amount of Acetogenins	Not Tested
Formulation	Only Soursop Leaf – which is proven safe and effective	Combination of other ingredients (effectiveness & safety is not proven); Added with prohibited drugs
Label	Transparent, standardized Annona muricata Soursop Leaf Extract 0.01-0.02% Acetogenins	Misleading claim (quantity), incorrect amount of Soursop Leaf extract, mostly filler ingredients

HALAL Certificate & High Standard Product Quality Control

HEALTH BENEFITS

Blood Sugar Control

In vivo study on effect of soursop leaf extract on blood sugar
Subject	Male rats (n=50)
Duration of the study	58 days
Dosage	50, 100, 150mg/kg
Groups	Negative control (Hyperglycemia) Positive control (Non hyperglycemia) Treatment (50mg/kg) Treatment (100mg/kg) Treatment (150mg/kg)
Parameters analysed	Fasting blood glucose level & pancreatic beta cell number
Function Soursop leaf extract can be used to treat diabetic individuals by lowering blood sugar and increasing beta cell number.	Visible benefits The soursop leaf extract dose of 100 mg/kg and 150 mg/kg affected the fasting blood glucose and pancreatic beta cell number which were exposed to a high-fat diet and streptozotocin.

Anti-cancer

In vivo study on effect of soursop leaf extract on cancer
Subject	Mice (n=20)
Duration of the study	8 weeks
Dosage	0, 100, 150 and 200 mg/kg /day
Groups	Negative control (C-) Positive control (C+) Treatment 1 (100mg/kg) Treatment 2 (150mg/kg) Treatment 3 (200mg/kg)
Parameters analysed	Oxidative enzyme level & tissue analysis
Function Soursop leaf extract may be used to treat breast cancer via antioxidant activity.	Visible benefits Soursop leaves extract with dose of 200 mg/kg increased the levels of SOD, and decreased the levels of MDA in mammary tissue and improved the cells of breast cancer back to normal.

Relieve Stress

In vivo study on effect of soursop leaf extract on stress
Subject	Healthy rats (n=36)
Duration of the study	65 days
Dosage	100, 200, 300 mg/kg /day
Groups	Negative control (No caffeine + No soursop) Positive control (Caffeine) Treatment 1 (Caffeine + 100mg/kg) Treatment 2 (Caffeine + 200mg/kg) Treatment 3 (Caffeine + 300mg/kg)
Parameters analysed	Oxidative stress markers level
Function Soursop leaf intervention can help in reducing daily stress.	Visible benefits A statistically significant decrease in the plasma level of superoxide dismutase (SOD), catalase activity (CAT) and glutathione peroxidase (GPx) when treated with caffeine compared to control. However, soursop leaf tea mitigated the oxidative stress caused by caffeine.