Annona muricata Extract

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STANDARDIZED Soursop Leaf extract

Annona muricata

Soursop Leaf (Annona muricata)
The popular fruit tree of Annona muricata (Annonaceae) commonly known as graviola or soursop is commercially cultured in Central and South America and tropical countries. The edible fruit of this small tropical tree is extensively used to produce candy, juice, smoothies, ice-cream and other sweet treats. In addition, this plant is also important due to its various applications in folk medicine. All parts of this plant, including the bark, fruit-seeds, leaves and root are used in natural medicines in the tropics. Traditionally, the leaves are used for cystitis, diabetes, headaches, hypertension, insomnia, liver problems and against skin diseases. Many people also use the soursop leaves to make tea.

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Blood Sugar Control

In vivo study on effect of soursop leaf extract on blood sugar

Subject Male rats (n=50)
Duration of the study 58 days
Dosage 50, 100, 150mg/kg
Groups (1) Negative control (Hyperglycemia) (2) Positive control (Non hyperglycemia) (3) Treatment (50mg/kg) (4) Treatment (100mg/kg) (5) Treatment (150mg/kg)
Parameters analysed Fasting blood glucose level & pancreatic beta cell number
Function Soursop leaf extract can be used to treat diabetic individuals by lowering blood sugar and increasing beta cell number. Visible benefits The soursop leaf extract dose of 100 mg/kg and 150 mg/kg affected the fasting blood glucose and pancreatic beta cell number which were exposed to a high-fat diet and streptozotocin.


In vivo study on effect of soursop leaf extract on cancer

Subject Mice (n=20)
Duration of the study 8 weeks
Dosage 0, 100, 150 and 200 mg/kg /day
Groups (1) Negative control (C-) (2) Positive control (C+) (3) Treatment 1 (100mg/kg) (4) Treatment 2 (150mg/kg) (5) Treatment 3 (200mg/kg)
Parameters analysed Oxidative enzyme level & tissue analysis
Function Soursop leaf extract may be used to treat breast cancer via antioxidant activity. Visible benefits Soursop leaves extract with dose of 200 mg/kg increased the levels of SOD, and decreased the levels of MDA in mammary tissue and improved the cells of breast cancer back to normal.

Relieve Stress

In vivo study on effect of soursop leaf extract on stress

Subject Healthy rats (n=36)
Duration of the study 65 days
Dosage 100, 200, 300 mg/kg /day
Groups (1) Negative control (No caffeine + No soursop)
(2) Positive control (Caffeine)
(3) Treatment 1 (Caffeine + 100mg/kg)
(4) Treatment 2 (Caffeine + 200mg/kg)
(5) Treatment 3 (Caffeine + 300mg/kg)
Parameters analysed Oxidative stress markers level
Soursop leaf intervention can help in reducing daily stress.
Visible benefits
-A statistically significant decrease in the plasma level of superoxide dismutase (SOD), catalase activity (CAT) and glutathione peroxidase (GPx) when treated with caffeine compared to control.
-However, soursop leaf tea mitigated the oxidative stress caused by caffeine.